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The investigation of the gating technique related to large-area, thin-walled components is described.

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How can thicker sections deviating from. New software products, new license models and completely unknown fem-method are aspects that affected employees have to deal with.

On the other hand there are many possibilities to support the employees by the use of a simulation soft. In order to analyse and control the dimensional quality created by SLM processes, an explicit numerical method has been developed by Altair to predict internal stresses and distortions.

This numerical tool allows to study the. The constant improvements of the CAE process from subsystem levels to the full car itself and the development of optimization tools to reduce the mass and increase the performances led us to use the simulation as one v. While many multiscale modeling frameworks exist, Multiscale Designer provides an unmatched combination of computational efficiency and predictive accuracy. Instead of implementing direct homoge.

After a brief introduction of the changes in the Energy Landscape, an analysis of the life of models will be presented from the viewpoint of system engineering. Along wi. RAMDO is an uncertainty quantification, reliability analysis, and design optimization software platform. This presentation will take you step-by-step through the electromagnetic and thermal analysis of a washing machine during a full wash cycle.

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By utilizing Flux and Activate, the designer was able to evaluate the thermal image of the motor, faster at a limited cost and in a limited time. Wnt10b acts as a paracrine factor and has a crucial role in inducing breast cancer epithelial cell EMT and facilitating metastasis. A study recently published in Nature Communications shows that breast cancer cells undergo a stiffening state prior to becoming malignant. The discovery, made by a research team led by Florence Janody, from Instituto Gulbenkian de Ciencia IGC; Portugal , identifies a new signal in tumor cells that could be applicable in the design of cancer-targeting therapies.

Tavares, S. Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells.

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Nature Communications, Published online: Researchers from Princeton University's Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of stem cells in both healthy and cancerous breast tissue. The study, which will be published in the June issue of Nature Cell Biology, suggests that this "microRNA" promotes particularly deadly forms of breast cancer and that inhibiting the effects of this molecule could improve the efficacy of existing breast cancer therapies.

While target therapies directed toward genetic mutations that drive a tumor's growth have significantly improved the outlook for many patients, they have not been as successful in controlling brain metastases in several types of cancer. In the case of breast cancer driven by overexpression of the HER2 gene, up to 50 percent of patients treated with targeted therapies eventually develop brain metastases, which are inevitably fatal.

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Kodack et al. Science Translational Medicine A City of Hope-led study found that the use of low-dose aspirin 81mg reduces the risk of breast cancer in women who are part of the California's Teacher's Study. This study—which is the first to suggest that the reduction in risk occurs for low-dose aspirin—was proposed by City of Hope's Leslie Bernstein, Ph.

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